Programme 2015 - Final Programme

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Programme 2015 - Final Programme

Transcript Of Programme 2015 - Final Programme

London on View

The 5th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures
9-11 April 2015 London, United Kingdom
Final Programme
www.statusepilepticus2015.eu

PATRONS
Paracelsus Medical University Christian Doppler Klinik Ignaz Harrer Strasse 79 A-5020 Salzburg, Austria
University College London Institute of Neurology Queen Square London WC 1N 3BG United Kingdom
CHAIRS
Simon Shorvon, London, United Kingdom Eugen Trinka, Salzburg, Austria
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Contents
WELCOME ......................................................................................................................................... 5 GENERAL INFORMATION. ................................................................................................................ 6 Information for Speakers & Poster presenters................................................................... 8 SCIENTIFIC PROGRAMME.................................................................................................................. 9
Thursday, 9 April 2015 ................................................................................................... 9 Friday, 10 April 2015 ..................................................................................................... 12 Saturday, 11 April 2015 ............................................................................................... 14 LIST OF FACULTY ........................................................................................................................... 16 LIST OF POSTERS ........................................................................................................................... 22 POSTER ABSTRACTS ...................................................................................................................... 33 SPONSORS AND EXHIBITORS ......................................................................................................... 88
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Dear friends and colleagues,

Welcome

Eugen Trinka

Simon Shorvon

It is our sincere pleasure to welcome you all to London, to this the 5th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures. These meetings have taken place biennially since 2007, and have become an important feature of the epilepsy calendar.

This year, the conference will focus on the clinical and experimental nature of status epilepticus and novel aspects of its treatment. It is our intention over the 3 days of the conference to have intensive and interactive discussion on the cutting edge of research and clinical practice in the field of status epilepticus. We hope to feature current basic and clinical research and to provide up-to-date reviews of the field. The aim of the meeting is to stimulate thought and discussion, and to lead to improvements in the treatment and outcome of this condition.

We have deliberately left space in the programme for the audience to question and to challenge - for we believe, as a fundamental pillar of the Colloquia, that academic debate is at the heart of all learning and discovery. We hope you will all join in this endeavour and contribute to what we hope will be a lively and instructive meeting.

Finally, some acknowledgements are in order. First, we would like to thank our conference organizing team, led by Mrs Ina Kähler, from PCO Tyrol Congress for their tremendous work. Also, the academic activities of this conference would not have been possible without the generous support of our sponsors listed at the back page of this booklet, and we offer our sincere thanks to them all. We are grateful too for the patronage of this conference by University College London and Paracelsus Medical University Salzburg.

With very best regards

Eugen Trinka and Simon Shorvon Co-Chairs, 5th London-Innsbruck Colloquium on Status Epilepticus and Actue Seizures

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General Information

Conference venue
Great Hall, Sherfield Building Imperial College, South Kensington Campus Londown SW7 2AZ, United Kingdom

Registration Desk at Sherfield Building

The registration will be located in the entrance area of the Sherfield Building, close to the

Queen‘s Tower Rooms

Opening hours are as follows:

Thursday, 9 April

7:30 – 17:30

Friday, 10 April

7:45 – 18:00

Saturday, 11 April

8:15 – 16:15

Congress Organisers
PCO Tyrol Congress Congress und Messe Innsbruck GmbH Ms. Ina Kähler and Ms. Sarah Fechner Rennweg 3 6020 Innsbruck, Austria T: +43-(0)512-575600, F:+43-(0)512-565707 E: [email protected] I: www.pco-tyrolcongress.at, www.cmi.at

Trade Exhibition
A trade exhibition of pharmaceutical companies and manufacturers of medical equipment is held in the Queen‘s Tower Rooms.

Exhibition Organisers
S12! studio 12 GmbH Mr. Ralph Kerschbaumer Kaiser Josef Straße 9 6020 Innsbruck, Austria T: +43-(0)512-890438, F: +43-(0)512-890438-15 E: [email protected]

Certificate of Attendance
All registered delegates receive an official certificate of attendance together with their registration documents.

Cloakroom
The cloakroom is located on the first floor of the Sherfield Building.

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General Information
Coffee breaks and refreshments
Coffee and tea will be served during the official coffee breaks. Lunch will also be provided. All refreshments are served in the exhibition area.
Smoking
Smoking is prohibited inside the Sherfield Building.
City Transportation
Arriving by London Underground From South Kensington Station, the campus is only a five minute walk. The College is located next to the Science Museum. Arriving by bus South Kensington Campus is easily accessible by bus. A number of routes pass within easy walking distance of the campus.
Currency
The official currency in the United Kingdom is the Pound. Major credit cards are accepted in most hotels, shops and restaurants. Automatic teller machines (ATMs) are available throughout the city.
Name Badges
All registered participants receive a name badge together with their registration documents. Please make sure to wear your badge at all times while attending the meeting, exhibition and social events.
Liability and Insurance
Neither the organisers, nor the congress secretariat or other suppliers accept liability for personal injuries or loss or damage of property belonging to congress delegates, either during or as a result of the Congress. It is recommended that participants arrange for their own personal health, accident and travel insurance.
Social Programme
Conference Dinner at the Royal College of Physicians (RCP) Food nourishes the brain and the soul, and at this the 2015 meeting, a rather splendid reception and dinner will be held at the Royal College of Physicians. In addition, there will be an opportunity also to visit the famous building of the College, see items from the College’s museum and library, and also to view the temporary exhibition of paintings of medicinal plants. Tickets are at EUR 55,00 p.p. Pre-booking is required as tickets are limited!
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Information for Speakers & Poster Presenters
Information for speakers
The Great Hall is equipped with a data projector and a PC for PowerPoint presentations. Please make sure to bring your PowerPoint presentation on a USB-stick to the media check well in advance, 2 hours prior to the start of your session at the very latest. Do not bring your own laptop for the presentation. In case your presentation contains video sequences, please ensure to pack them with a standard codec and do not store them in a Quick Time format since this may not be compatible with PowerPoint presentations. In order to be able to keep the time schedule, please make sure not to exceed the allotted speaking time.
Information for poster presenters
The poster session is held on Friday, 10th April from 11:55 – 14:00 in the Queen‘s Tower Rooms (Sherfield Building). POSTER FORMAT: Your poster should not exceed 90 cm in width and 150 cm in height (portrait NOT landscape format). Mounting material will be provided on site. All posters will be displayed during the entire congress and should be mounted on 9th April in the morning. Posters have to be displayed during the whole congress and have to be taken down on Saturday 11th April by the end of the colloquium. Please note that all posters which have not been taken down by their presenters will automatically be removed and discarded. POSTER PRESENTATION DETAILS: During the session you or one of your co-authors must be at your poster site and be prepared to answer questions.
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THURSDAY APRIL 9th 2015 Scientific Programme

08.30 - 12.30 08.30 - 08.40 08.40 - 09.15 09.15 – 09.50 09.50 - 10.20 10.20 – 10.55 10.55 - 11.30 11.30 - 12.05

THE NATURE OF SE: EXPERIMENTAL ASPECTS
Chair: D. Kullmann (United Kingdom) and J. Kapur (USA)
Welcome and introduction S. Shorvon (United Kingdom) and E. Trinka (Austria)
Is hypoxia important in status epilepticus? G. Biagini (Italy)
Structural and functional changes in astrocytes following status epilepticus K. Wilcox (USA)
Coffee Break
Chair: D. Lowenstein (USA) and A. Rossetti (Switzerland)
What are the physiological bases of GPEDs and other EEG patterns in status epilepticus? M. van Putten (The Netherlands)
Is spreading depression important in status epilepticus? J. Dreier (Germany)
What does burst suppression really mean? F. Amzica (Canada)

12.05 – 12.30

Lunch

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Scientific Programme

12.30 – 13.30
12.30 – 12.35 12.35 – 13.00 13.00 – 13.25 13.25 – 13.30

SATELLITE SYMPOSIUM: STATUS EPILEPTICUS – FROM BENCH TO BEDSIDE – CHALLENGES FOR TRANSLATING NEW MECHANISMS INTO NEW TREATMENTS (Sponsored by Industry)
Co-Chairs: E. Trinka (Austria) and S. Shorvon (United Kingdom)
Introduction E. Trinka (Austria) and S. Shorvon (United Kingdom)
Animal models of status epilepticus: perspectives on predictability and translation M. Walker (United Kingdom)
Clinical trials for status epilepticus: perspectives on feasibility A. Rossetti (Switzerland)
Concluding remarks E. Trinka (Austria) and S. Shorvon (United Kingdom)

13.30 – 14.00

PANEL DISCUSSION
Chair: M. Baulac (France)
The conference perspective on translating new mechanisms into new treatments

14.00 - 17.30 14.00 - 14.30 14.30 - 15.00

THE NATURE OF STATUS EPILEPTICUS: CLINICAL ASPECTS
Chair: H. Cross (United Kingdom) and R. Guerrini (Italy)
Pathophysiology of mitochondrial disease causing status epilepticus S. Rahman (United Kingdom)
Status epilepticus, inflammation and blood brain barrier disruption J. Gorter (The Netherlands)

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15.00 - 15.30 15.30 - 16.00 16.00 - 16.30 16.30 – 17.00 17.00 - 17.30
19.30 - 23.00

Scientific Programme
P2X receptor as a link between hyperexcitability and neuroinflammation in status epilepticus D. Henshall (Ireland)
Coffee Break
Chair: N. Bharucha (India) and C. Wasterlain (USA)
Gene mutations associated with status epilepticus S. Shorvon (United Kingdom)
Predicting the outcome of status epilepticus M. Leitinger (Austria)
Expert Panel Discussion: The experimental and clinical nature of status epilepticus
Chair: E. Trinka (Austria)
M. Cook (Australia), R. Guerrini (Italy), J. Kapur (USA), D. Lowenstein (USA), A. Rossetti (Switzerland), C. Wasterlain (USA)
RECEPTION AND DINNER (Royal College of Physicians)

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Scientific Programme FRIDAY APRIL 10th 2015

08.30 - 12.30 08.30 - 09.05 09.05 - 09.40 09.40 - 10.15 10.15 - 10.45 10.45 - 11.20 11.20 - 11.55

CLINICAL ASPECTS OF STATUS EPILEPTICUS
Chair: M. Koepp (United Kingdom) and D. Lowenstein (USA)
The nature of neonatal status epilepticus D. Dlugos (USA)
Drug induced status epilepticus H. Cock (United Kingdom)
Can anaesthetic treatment worsen outcome in status epilepticus? R. Sutter (Switzerland)
Coffee Break
Chair: T. Bleck (USA) and R. Guerrini (Italy)
Systemic complications of status epilepticus S. Hocker (USA)
Audit of treatment in refractory status epilepticus M. Ferlisi (Italy)

11.55 – 14.00

CONFERENCE PHOTOGRAPH, POSTERS AND LUNCH

14.00 – 15.00 14.00 – 14.30 14.30 – 15.00 15.00 - 15.30

MINI-SYMPOSIUM: CANNABINOIDS AND STATUS EPILEPTICUS
Cannabinoid pharmacology in preclinical models of seizure, status and epilepsy B. J. Whalley (United Kingdom)
Emerging clinical effects of cannabinoids in epilepsy H. Cross (United Kingdom)
Tea Break

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15.30 - 17.15
15.30 - 16.00 16.00 - 16.30 16.30 - 17.00 17.00 – 17.15 17.15 - 18.00

Scientific Programme
ELECTROGRAPHIC STATUS EPILEPTICUS
Chair: R. Pressler (United Kingdom) and A. Rossetti (Switzerland)
Electrographic status epilepticus in critically ill children: epidemiology and outcome N. Abend (USA)
Outcome of electrographic status epilepitcus T. Loddenkemper (USA)
Which EEG Patterns in Coma are nonconvulsive status epilepticus? E. Trinka (Austria)
GPEDs and status epilepticus – a matter of frequency? M. Koutroumanidis (United Kingdom)
DEBATE
Chair: S. Shorvon (United Kingdom)
Motion: Should PEDs (and similar EEG Patterns) in post-anoxic status epilepticus be treated ? Pro: L. Hirsch (USA) Contra: P. Kaplan (USA)

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Scientific Programme SATURDAY APRIL 11th 2015

08.45 - 12.00
08.45 – 9.00 09.00 - 09.30 09.30 - 10.00 10.00 - 10.30 10.30 – 11.00

NOVEL ASPECTS IN THE DRUG TREATMENT OF status epilepticus
Chair: C. Wasterlain (USA)
Invited lecture: System mechanisms of anti-epileptic protection V. Karlov (Moscow)
Intranasal therapies of acute seizures R. Kälviainen (Finland)
Intramuscular and rectal therapies of acute seizures I. Leppik (USA)
SPD and valnoctamide M. Bialer (Israel)
Coffee Break

11.00 - 12.00 11.00 – 11.30 11.30 – 12.00

MINI SYMPOSIUM: NEUROSTEROIDS (Sponsored by Industry )
SAGE 689, a second generation neuroactive steroid for status epilepticus A. Robichaud (USA)
SAGE 547, for super refractory status epilepticus; a clinical update S. Kanes (USA)

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12.00 - 12.30 12.30 – 13.45 12.30 - 13.00 13.00 - 13.30
13.30 - 13.45 13.45 - 16.15
13.45- 14.15 14.15 - 14.45 14.45 – 15.15 15.15 – 15.45 15.45 – 16.15 16.15

LUNCH

Scientific Programme

SPECIAL SYMPOSIUM: SEIZURE CLUSTERS (Supported by an educational grant by Industry)
Can we predict seizure clusters? - Insights from neurophysiology T. Loddenkemper (USA)
Seizure clusters and serial seizures - a clinical entity or part of a continuum? M. Holtkamp (Germany)

Discussion

NOVEL ASPECTS IN THE DRUG TREATMENT OF status epilepticus
Chair: J. Kapur (USA) and T. Bleck (USA)
New experimental therapies in pre-clinical development M. Walker (United Kingdom)
Single v. combinational therapies in status epilepticus W. Löscher (Germany)
A tale of two receptors: synergistic drug combinations for status epilepticus C. Wasterlain (USA)
Propofol Hemisuccinate M. Rogawski (USA)
Lacosamide A. Husain (USA)

END OF COLLOQUIUM AND TEA

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List of Faculty
Abend Nicholas, Prof. Dr. Ass. Prof. of Neurology and Pediatrics, University of Pennsylvania Children’s Hospital of Pennsylvania Philadelphia PA 19146, USA [email protected]
Amzica Florin, Prof. Professor, Université De Montréal Dept. of Stomatology /Neuroscience Montréal H3C 3J7, Canada [email protected]
Baulac Michel, Prof. Département de Neurologie Hôpital de la Salpétrière Paris, France [email protected]
Bharucha Nadir, Prof. Head of the Dept. of Neurology, Bombay Hospital Inst. of Medical Sciences Mumbai 400020, India [email protected]
Biagini Giuseppe, Dr. Associate Professor, University of Modena and Reggio Emilia Biomedical, Metabolic and Neural Sciences 41125 Modena, Italy [email protected]
Bialer Meir, Prof. David H. Eisenberg Professor, Hebrew University Faculty of Medicine Jerusalem, Israel [email protected]
Bleck Thomas, Prof. Chief of Critical Care, Rush University Medical Center Dept. of Neurology Chicago 60612, USA [email protected];[email protected]
Cock Hannah, Dr. Dept. of Neurology London SW17 0QT, United Kingdom [email protected]
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Cook Mark, Prof. Director of Neurosciences St . Vincent’s Hospital Fitzroy/Melbourne, Australia [email protected]
Cross Helen, Prof. The Prince of Wales’s Chair of Childhood Epilepsy, Deputy Head of Developmental Neurosciences, University College London-Institute of Child Health London, WCIN WC1N 3LU, United Kingdom [email protected]
Dlugos Dennis, Prof. Professor of Pediatrics, The Children’s Hospital of Philadelphia Perelman School of Medicine At The University of Philadelphia Philadelphia 19063, USA [email protected]
Dreier Jens, Prof. Dr. Univ.-Prof., Charité University Medicine Berlin Center For Stroke Research Berlin 10117 Berlin, Germany [email protected]
Ferlisi Monica, Dr. Neurology Consultant, University Hospital of Verona Unit of Neurology A 37126 Verona, Italy [email protected]
Gorter Jan, Dr. Assist. Prof., University of Amsterdam Swammerdam Institute for Life Sciences Amsterdam, Netherlands [email protected]
Guerrini Renzo, Prof. Director Paediatric Neurology Unit, University of Firenze Children’s Hospital A. Meyer 50139 Florence, Italy [email protected];[email protected]

List of Faculty

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List of Faculty
Henshall David, Prof. Royal College of Surgeons In Ireland Physiology and Medical Physics Dublin 2, Ireland [email protected]
Hirsch Lawrence J., Dr. Director, Div. of Epilepsy and EEG, Yale University Dept. of Neurology New Haven CT 065208018, USA [email protected]
Hocker Sara, Dr. Consultant, Mayo Clinic Dept. of Neurology Rochester MW 55906, USA [email protected]
Holtkamp, Prof. Dr. Epilepsy-Center Berlin-Brandenburg Department of Neurology Charité - University Medicine Berlin Berlin, Germany [email protected]
Husain Aatif, Prof. Duke University Medical Center Dept. of Neurology Durham NC 27710, USA [email protected]
Kälviäinen Reetta, Prof. Kuopio University Hospital, Univ. of Eastern Finland & Kuopio Epilepsy Center Dept. of Neurology Kys, Finland [email protected]
Kaplan Peter, Prof. Director of EEG-/Epilepsy Bayview, Johns Hopkins Bayview Medical Center Dept. of Neurology Baltimore MD 21224, USA [email protected]
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Kapur Jaideep, Prof. Neurologist, University of Virginia Dept. of Neurology Charlottesville 22908, USA [email protected]
Karlov Vladimir, Prof. Professor of Neurology Moscow State University of Medicine and Dentistry Moscow, Russia [email protected]
Koepp Matthias, Prof. Professor of Clinical Neurology UCL Institute of Neurology London, WC1N 3BG, United Kingdom [email protected]
Koutroumanidis Michalis, Prof. Consultant Epileptologist Neurophysiologist Department of Clin Neurophysiology and Epilepsy St Thomas’ Hospital London SE1 7EH United Kingdom [email protected]
Kullmann Dimitri, Prof. Professor of Neurology, UCL Institute of Neurology London, WC1n 3BG, United Kingdom [email protected]
Leitinger Markus, Dr. Paracelsus Medical University Salzburg Dept. of Neurology 5020 Salzburg, Austria [email protected]
Leppik Ilo, Prof. Professor, University of Minnesota Dept. of Pharmacy and Neurology Minneapolis MN 55427, USA [email protected]
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List of Faculty
ProfStatus EpilepticusKingdomCollegeProfessor