1st International Young Investigator Symposium Program
Transcript Of 1st International Young Investigator Symposium Program
1st International Young Investigator Symposium Program
Day 1
March 4, Thursday
9:00-9:30 9.30-9:50
9:50-10:30 10:30-11:00
6th floor, GTC 9:30 - 17:10
[20] Plenary
[40]
[30]
Registration Opening Remark
Hiroaki Mitsuya Talk I and Joint Session I
Chair: Takamasa Ueno
01 Paul L. Boyer (National Cancer Institute, USA) Plenary Talk
02 Takeo Kuwata (Kumamoto Univ.)
(Director for AIDS gCOE, Kumamoto Univ.) 9:50-12:00 [130] and Hirotomo Nakata
Contribution of antibody response to effective suppression and progression of disease during
viral SIV infection
11:00-11:30
[30] 03 Ryuta Sakuma
Rhesus Monkey TRIM5alpha Mediated-Late Restriction of
(Tokyo Medical and Dental Univ.) HIV-1 Lifecycle
11:30-12:00
[30] 04 Guillaume B.E. Stewart-Jones (University of Oxford, UK)
12:00-14:00 14:00-14:20 14:20-14:40 14:40-15:00
[120] Parallel Session II: Immune Responses I
Chairs: Madoka [20] 05 Masao Hashimoto
(Kumamoto Univ.)
[20] 06 Tetsuo Tsukamoto (University of Tokyo)
[20] 07 Chihiro Motozono (Kumamoto Univ.)
Lunch / Panel Discussion I
14:00-15:30 [90] Koyanagi and Kazutaka Honda
Comprehensive analysis of escape mutation from HIV-1-specific cytotoxic T cells restricted by Asian allele HLA-B*5401 Benefit of single epitope-specific CD8+ T-cell memory induction without virus-specific CD4+ T-cell help for
immunodeficiency virus control T cell receptor cross-reactivity toward variant HIV antigens is dependent on cognate peptide specificity
15:00-15:30
[30] 08 Jeffrey J. Ishizuka
Models of Protection and Pathogenesis in HIV-1 Immune
(Harvard Medical School, USA) Activation
15:30-16:00 16:00-16:20
[30]
Coffee Break
Parallel Session II: Pathogenesis I
16:00-17:10 [70]
Chairs: Shigeyoshi Harada and Terumasa Ikeda
[20] 09 Ranya Hassan
A unique function of HIV-1 Nef that depends on its highest
(Kumamoto Univ.)
affinity host factor Hck
16:20-16:40
[20] 10 Masateru Hiyoshi (Kumamoto Univ.)
Molecular mechanism by which HIV-1 Nef-Hck axis induces the Golgi dys-function
16:40-17:10
[30] 11 Kei Sato (Kyoto Univ.)
A novel HIV-1 infection model using humanized mice
19:00-21:00
[120]
Welcome reception: Shiromiyagura(城見櫓)
4
2nd floor, CAIDS 14:00 - 17:10
14:00-14:20 14:20-14:40 14:40-15:00
Parallel Session [20] 12 [20] 13 [20] 14
III: Drug Resistance I
14:00-15:30 [90]
Chairs: Kazuhisa Yoshimura and Yasushi Tojo
Shigeyoshi Harada
In vitro selections of raltegravir resistant variants using
(Kumamoto Univ.)
diverse primary isolates, subtype B, C, CRF01_AE, and
CRF08_BC
Masako Nisizawa
Analyses of minority drug-resistant populations in
(National Institute of
newly-diagnosed HIV/AIDS patients in Japan using highly
Infectious Diseases) sensitive allele-specific PCR
Kazuhiko Ide
Novel HIV-1 protease inhibitors (PIs) containing
(Kumamoto Univ.)
bis-tetrahydrofuran (bis-THF) and a novel polycyclic ligand
15:00-15:30 15:30-16:00 16:00-16:20 16:20-16:40
[30] 15
[30] Parallel Session
[20] 16
[20] 17
Hiromi Aoki (Kumamoto Univ.)
IV: Drug Resistance II Chairs: Nobuyo
Takashi Masaoka (Nagoya Medical Center)
Masayuki Amano (Kumamoto Univ.)
Early phase dynamics of HIV-1 infection in hPBM-transplanted NOD/SCID/Jak3-/- mice using infectious HIV-1 carrying fluorescent protein mCherry
Coffee Break
16:00-17:10 [70] Kuwata and Hiromi Aoki
Novel high-throughput phenotypic resistance assay for HIV-1 protease using wheat cell-free protein production system Inserts in Gag Proteins Elicit Degradation of the Gag Proteins in Multi-drug-resistant HIV Variants
16:40-17:10 19:00-21:00
[30] [120]
18 Manabu Aoki (Kumamoto Univ.)
The binary mechanism of HIV-1 resistance to tipranavir
(TPV): Loss of inhibition of protease catalytic activity and
protease dimerization Welcome reception: Shiromiyagura(城見櫓)
5
1st International Young Investigator Symposium Program
Day 2
9:30-10:10 10:10-10:40
March 5, Friday
6th floor, GTC 9:30 - 17:20
Plenary talk II and Joint Session II
9:30-12:10 [160]
Chairs: Shinya Suzu and Keiko Sakai
[40] 19 Tao Dong
Extensive HLA-driven viral diversity following a
(University of Oxford, UK)
single-source HIV-1 outbreak in rural China
Plenary Talk
[30] 20 Hirotomo Nakata
CCR5 receptors form functional clusters upon their
(National Cancer Institute, USA) interactions with HIV gp120/gp41 trimers
10:40-11:10
[30] 21 Shogo Misumi (Kumamoto Univ.)
UNCOATING OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REQUIRES PROLYL ISOMERASE PIN1
11:10-11:40 11:40-12:10
[30] 22 Kosuke Miyauchi
The productive endocytosis of HIV-1
(National Institute of
Infectious Diseases)
[20] 23 Joseph Ziegelbauer
Human target genes of viral microRNAs expressed by
(National Cancer Institute, USA) Kaposi's sarcoma-associated herpesvirus
12:10-14:10
[120]
Lunch / Panel Discussion II
Parallel Session V: Immune Responses II
14:10-15:30 [80]
Chairs: Masao Hashimoto and Hayato Murakoshi
14:10-14:30
[20] 24 Hiroyuki Yamamoto
Non-sterile SIV control by neutralizing antibodies: window
(University of Tokyo)
period for a B-to-T.
14:30-14:50
[20] 25 Teppei Toda (Kumamoto Univ.)
Inhibition of HIV-1 infection by novel anti-CD4 monoclonal antibody
14:50-15:10
[20] 26 Philip Mwimanzi (Kumamoto Univ.)
The effects of CTL-escape conferring mutations on Nef's pathogenic functions in primary macrophages.
15:10-15:30
[20] 27 Kazutaka Honda (Kumamoto Univ.)
15:30-16:00
[30]
Parallel Session VI: Immune Responses III
Chairs: Masumichi
16:00-16:30
[30] 28 Maximillian Rosario
(University of Oxford, UK)
16:30-16:50
[20] 29 Nan Zheng (Kumamoto Univ.)
Saito
Selection of escape mutant by HLA-C-restricted HIV-1 Pol-specific cytotoxic T lymphocytes having a strong ability to suppress HIV-1 replication
Coffee Break
16:00-17:10 [70] and Chihiro Motozono
Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques Roles of CD4+ T Cells in the Control of HIV Infection: The Victim Strikes Back
16:50-17:10 17.10-17:20
[20] 30 Keiko Sakai (Kumamoto Univ.)
[10] Closing Remark
Correlation between nadir CD4 counts and skewed distributions of CD4+ T-cell subsets in patients chronically infected with HIV-1
6
2nd floor, CAIDS 14:10 - 17:20
Parallel Session VII: Therapy and Epidemiology
14:10-15:30 [80]
Chairs: Hiroyuki Gatanaga and Kazuhiko Ide
14:10-14:30
[20] 31 Takeshi Nishijima
The impact of Tenofovir disoproxil fumarate on renal
(International Medical
function among Japanese patients with HIV-1 infection
Center of Japan)
14:30-14:50
[20] 32 Tamayo Watanabe
Trends of AIDS indicative diseases, malignancies, and cause
(International Medical
of death in HIV-1-infected patients in Japan.
Center of Japan)
14:50-15:10
[20] 33 Jagdagsuren Davaalkham
Current status of HIV infection in Mongolia: Expanding
(International Medical
trend of HIV-1 subtype B among MSM
Center of Japan)
15:10-15:30
[20] 34 Shiro Ibe
Identification of the first circulating recombinant form of
(Nagoya Medical Center)
HIV-2, CRF01_AB
15:30-16:00 16:00-16:30 16:30-16:50
[30]
Coffee Break
Parallel Session VIII: Pathogenesis II
16:00-17:10 [70]
Chairs: Takeo Kuwata and Masateru Hiyoshi
[30] 35 Ken Kono
Viral and host determinants for the restriction of human
(Osaka Univ.)
immunodeficiency virus type 2/simian immunodeficiency
[20] 36 Taisuke Izumi
virus SIVmac by rhesus monkey TRIM5α A novel HIV-1 Vif function is mediated by interaction with
(Kyoto Univ.)
oncoprotein p53
16:50-17:10 17.10-17:20
[20] 37 Terumasa Ikeda (Kumamoto University)
[10] Closing Remark
Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons
7
Day 1
March 4, Thursday
9:00-9:30 9.30-9:50
9:50-10:30 10:30-11:00
6th floor, GTC 9:30 - 17:10
[20] Plenary
[40]
[30]
Registration Opening Remark
Hiroaki Mitsuya Talk I and Joint Session I
Chair: Takamasa Ueno
01 Paul L. Boyer (National Cancer Institute, USA) Plenary Talk
02 Takeo Kuwata (Kumamoto Univ.)
(Director for AIDS gCOE, Kumamoto Univ.) 9:50-12:00 [130] and Hirotomo Nakata
Contribution of antibody response to effective suppression and progression of disease during
viral SIV infection
11:00-11:30
[30] 03 Ryuta Sakuma
Rhesus Monkey TRIM5alpha Mediated-Late Restriction of
(Tokyo Medical and Dental Univ.) HIV-1 Lifecycle
11:30-12:00
[30] 04 Guillaume B.E. Stewart-Jones (University of Oxford, UK)
12:00-14:00 14:00-14:20 14:20-14:40 14:40-15:00
[120] Parallel Session II: Immune Responses I
Chairs: Madoka [20] 05 Masao Hashimoto
(Kumamoto Univ.)
[20] 06 Tetsuo Tsukamoto (University of Tokyo)
[20] 07 Chihiro Motozono (Kumamoto Univ.)
Lunch / Panel Discussion I
14:00-15:30 [90] Koyanagi and Kazutaka Honda
Comprehensive analysis of escape mutation from HIV-1-specific cytotoxic T cells restricted by Asian allele HLA-B*5401 Benefit of single epitope-specific CD8+ T-cell memory induction without virus-specific CD4+ T-cell help for
immunodeficiency virus control T cell receptor cross-reactivity toward variant HIV antigens is dependent on cognate peptide specificity
15:00-15:30
[30] 08 Jeffrey J. Ishizuka
Models of Protection and Pathogenesis in HIV-1 Immune
(Harvard Medical School, USA) Activation
15:30-16:00 16:00-16:20
[30]
Coffee Break
Parallel Session II: Pathogenesis I
16:00-17:10 [70]
Chairs: Shigeyoshi Harada and Terumasa Ikeda
[20] 09 Ranya Hassan
A unique function of HIV-1 Nef that depends on its highest
(Kumamoto Univ.)
affinity host factor Hck
16:20-16:40
[20] 10 Masateru Hiyoshi (Kumamoto Univ.)
Molecular mechanism by which HIV-1 Nef-Hck axis induces the Golgi dys-function
16:40-17:10
[30] 11 Kei Sato (Kyoto Univ.)
A novel HIV-1 infection model using humanized mice
19:00-21:00
[120]
Welcome reception: Shiromiyagura(城見櫓)
4
2nd floor, CAIDS 14:00 - 17:10
14:00-14:20 14:20-14:40 14:40-15:00
Parallel Session [20] 12 [20] 13 [20] 14
III: Drug Resistance I
14:00-15:30 [90]
Chairs: Kazuhisa Yoshimura and Yasushi Tojo
Shigeyoshi Harada
In vitro selections of raltegravir resistant variants using
(Kumamoto Univ.)
diverse primary isolates, subtype B, C, CRF01_AE, and
CRF08_BC
Masako Nisizawa
Analyses of minority drug-resistant populations in
(National Institute of
newly-diagnosed HIV/AIDS patients in Japan using highly
Infectious Diseases) sensitive allele-specific PCR
Kazuhiko Ide
Novel HIV-1 protease inhibitors (PIs) containing
(Kumamoto Univ.)
bis-tetrahydrofuran (bis-THF) and a novel polycyclic ligand
15:00-15:30 15:30-16:00 16:00-16:20 16:20-16:40
[30] 15
[30] Parallel Session
[20] 16
[20] 17
Hiromi Aoki (Kumamoto Univ.)
IV: Drug Resistance II Chairs: Nobuyo
Takashi Masaoka (Nagoya Medical Center)
Masayuki Amano (Kumamoto Univ.)
Early phase dynamics of HIV-1 infection in hPBM-transplanted NOD/SCID/Jak3-/- mice using infectious HIV-1 carrying fluorescent protein mCherry
Coffee Break
16:00-17:10 [70] Kuwata and Hiromi Aoki
Novel high-throughput phenotypic resistance assay for HIV-1 protease using wheat cell-free protein production system Inserts in Gag Proteins Elicit Degradation of the Gag Proteins in Multi-drug-resistant HIV Variants
16:40-17:10 19:00-21:00
[30] [120]
18 Manabu Aoki (Kumamoto Univ.)
The binary mechanism of HIV-1 resistance to tipranavir
(TPV): Loss of inhibition of protease catalytic activity and
protease dimerization Welcome reception: Shiromiyagura(城見櫓)
5
1st International Young Investigator Symposium Program
Day 2
9:30-10:10 10:10-10:40
March 5, Friday
6th floor, GTC 9:30 - 17:20
Plenary talk II and Joint Session II
9:30-12:10 [160]
Chairs: Shinya Suzu and Keiko Sakai
[40] 19 Tao Dong
Extensive HLA-driven viral diversity following a
(University of Oxford, UK)
single-source HIV-1 outbreak in rural China
Plenary Talk
[30] 20 Hirotomo Nakata
CCR5 receptors form functional clusters upon their
(National Cancer Institute, USA) interactions with HIV gp120/gp41 trimers
10:40-11:10
[30] 21 Shogo Misumi (Kumamoto Univ.)
UNCOATING OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REQUIRES PROLYL ISOMERASE PIN1
11:10-11:40 11:40-12:10
[30] 22 Kosuke Miyauchi
The productive endocytosis of HIV-1
(National Institute of
Infectious Diseases)
[20] 23 Joseph Ziegelbauer
Human target genes of viral microRNAs expressed by
(National Cancer Institute, USA) Kaposi's sarcoma-associated herpesvirus
12:10-14:10
[120]
Lunch / Panel Discussion II
Parallel Session V: Immune Responses II
14:10-15:30 [80]
Chairs: Masao Hashimoto and Hayato Murakoshi
14:10-14:30
[20] 24 Hiroyuki Yamamoto
Non-sterile SIV control by neutralizing antibodies: window
(University of Tokyo)
period for a B-to-T.
14:30-14:50
[20] 25 Teppei Toda (Kumamoto Univ.)
Inhibition of HIV-1 infection by novel anti-CD4 monoclonal antibody
14:50-15:10
[20] 26 Philip Mwimanzi (Kumamoto Univ.)
The effects of CTL-escape conferring mutations on Nef's pathogenic functions in primary macrophages.
15:10-15:30
[20] 27 Kazutaka Honda (Kumamoto Univ.)
15:30-16:00
[30]
Parallel Session VI: Immune Responses III
Chairs: Masumichi
16:00-16:30
[30] 28 Maximillian Rosario
(University of Oxford, UK)
16:30-16:50
[20] 29 Nan Zheng (Kumamoto Univ.)
Saito
Selection of escape mutant by HLA-C-restricted HIV-1 Pol-specific cytotoxic T lymphocytes having a strong ability to suppress HIV-1 replication
Coffee Break
16:00-17:10 [70] and Chihiro Motozono
Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques Roles of CD4+ T Cells in the Control of HIV Infection: The Victim Strikes Back
16:50-17:10 17.10-17:20
[20] 30 Keiko Sakai (Kumamoto Univ.)
[10] Closing Remark
Correlation between nadir CD4 counts and skewed distributions of CD4+ T-cell subsets in patients chronically infected with HIV-1
6
2nd floor, CAIDS 14:10 - 17:20
Parallel Session VII: Therapy and Epidemiology
14:10-15:30 [80]
Chairs: Hiroyuki Gatanaga and Kazuhiko Ide
14:10-14:30
[20] 31 Takeshi Nishijima
The impact of Tenofovir disoproxil fumarate on renal
(International Medical
function among Japanese patients with HIV-1 infection
Center of Japan)
14:30-14:50
[20] 32 Tamayo Watanabe
Trends of AIDS indicative diseases, malignancies, and cause
(International Medical
of death in HIV-1-infected patients in Japan.
Center of Japan)
14:50-15:10
[20] 33 Jagdagsuren Davaalkham
Current status of HIV infection in Mongolia: Expanding
(International Medical
trend of HIV-1 subtype B among MSM
Center of Japan)
15:10-15:30
[20] 34 Shiro Ibe
Identification of the first circulating recombinant form of
(Nagoya Medical Center)
HIV-2, CRF01_AB
15:30-16:00 16:00-16:30 16:30-16:50
[30]
Coffee Break
Parallel Session VIII: Pathogenesis II
16:00-17:10 [70]
Chairs: Takeo Kuwata and Masateru Hiyoshi
[30] 35 Ken Kono
Viral and host determinants for the restriction of human
(Osaka Univ.)
immunodeficiency virus type 2/simian immunodeficiency
[20] 36 Taisuke Izumi
virus SIVmac by rhesus monkey TRIM5α A novel HIV-1 Vif function is mediated by interaction with
(Kyoto Univ.)
oncoprotein p53
16:50-17:10 17.10-17:20
[20] 37 Terumasa Ikeda (Kumamoto University)
[10] Closing Remark
Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons
7