1st International Young Investigator Symposium Program

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1st International Young Investigator Symposium Program

Transcript Of 1st International Young Investigator Symposium Program

1st International Young Investigator Symposium Program

Day 1

March 4, Thursday

9:00-9:30 9.30-9:50
9:50-10:30 10:30-11:00

6th floor, GTC 9:30 - 17:10

[20] Plenary
[40]
[30]

Registration Opening Remark
Hiroaki Mitsuya Talk I and Joint Session I
Chair: Takamasa Ueno
01 Paul L. Boyer (National Cancer Institute, USA) Plenary Talk
02 Takeo Kuwata (Kumamoto Univ.)

(Director for AIDS gCOE, Kumamoto Univ.) 9:50-12:00 [130] and Hirotomo Nakata
Contribution of antibody response to effective suppression and progression of disease during

viral SIV infection

11:00-11:30

[30] 03 Ryuta Sakuma

Rhesus Monkey TRIM5alpha Mediated-Late Restriction of

(Tokyo Medical and Dental Univ.) HIV-1 Lifecycle

11:30-12:00

[30] 04 Guillaume B.E. Stewart-Jones (University of Oxford, UK)

12:00-14:00 14:00-14:20 14:20-14:40 14:40-15:00

[120] Parallel Session II: Immune Responses I
Chairs: Madoka [20] 05 Masao Hashimoto
(Kumamoto Univ.)
[20] 06 Tetsuo Tsukamoto (University of Tokyo)
[20] 07 Chihiro Motozono (Kumamoto Univ.)

Lunch / Panel Discussion I
14:00-15:30 [90] Koyanagi and Kazutaka Honda
Comprehensive analysis of escape mutation from HIV-1-specific cytotoxic T cells restricted by Asian allele HLA-B*5401 Benefit of single epitope-specific CD8+ T-cell memory induction without virus-specific CD4+ T-cell help for
immunodeficiency virus control T cell receptor cross-reactivity toward variant HIV antigens is dependent on cognate peptide specificity

15:00-15:30

[30] 08 Jeffrey J. Ishizuka

Models of Protection and Pathogenesis in HIV-1 Immune

(Harvard Medical School, USA) Activation

15:30-16:00 16:00-16:20

[30]

Coffee Break

Parallel Session II: Pathogenesis I

16:00-17:10 [70]

Chairs: Shigeyoshi Harada and Terumasa Ikeda

[20] 09 Ranya Hassan

A unique function of HIV-1 Nef that depends on its highest

(Kumamoto Univ.)

affinity host factor Hck

16:20-16:40

[20] 10 Masateru Hiyoshi (Kumamoto Univ.)

Molecular mechanism by which HIV-1 Nef-Hck axis induces the Golgi dys-function

16:40-17:10

[30] 11 Kei Sato (Kyoto Univ.)

A novel HIV-1 infection model using humanized mice

19:00-21:00

[120]

Welcome reception: Shiromiyagura(城見櫓)

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2nd floor, CAIDS 14:00 - 17:10

14:00-14:20 14:20-14:40 14:40-15:00

Parallel Session [20] 12 [20] 13 [20] 14

III: Drug Resistance I

14:00-15:30 [90]

Chairs: Kazuhisa Yoshimura and Yasushi Tojo

Shigeyoshi Harada

In vitro selections of raltegravir resistant variants using

(Kumamoto Univ.)

diverse primary isolates, subtype B, C, CRF01_AE, and

CRF08_BC

Masako Nisizawa

Analyses of minority drug-resistant populations in

(National Institute of

newly-diagnosed HIV/AIDS patients in Japan using highly

Infectious Diseases) sensitive allele-specific PCR

Kazuhiko Ide

Novel HIV-1 protease inhibitors (PIs) containing

(Kumamoto Univ.)

bis-tetrahydrofuran (bis-THF) and a novel polycyclic ligand

15:00-15:30 15:30-16:00 16:00-16:20 16:20-16:40

[30] 15
[30] Parallel Session
[20] 16
[20] 17

Hiromi Aoki (Kumamoto Univ.)
IV: Drug Resistance II Chairs: Nobuyo
Takashi Masaoka (Nagoya Medical Center)
Masayuki Amano (Kumamoto Univ.)

Early phase dynamics of HIV-1 infection in hPBM-transplanted NOD/SCID/Jak3-/- mice using infectious HIV-1 carrying fluorescent protein mCherry
Coffee Break
16:00-17:10 [70] Kuwata and Hiromi Aoki
Novel high-throughput phenotypic resistance assay for HIV-1 protease using wheat cell-free protein production system Inserts in Gag Proteins Elicit Degradation of the Gag Proteins in Multi-drug-resistant HIV Variants

16:40-17:10 19:00-21:00

[30] [120]

18 Manabu Aoki (Kumamoto Univ.)

The binary mechanism of HIV-1 resistance to tipranavir
(TPV): Loss of inhibition of protease catalytic activity and
protease dimerization Welcome reception: Shiromiyagura(城見櫓)

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1st International Young Investigator Symposium Program

Day 2
9:30-10:10 10:10-10:40

March 5, Friday

6th floor, GTC 9:30 - 17:20

Plenary talk II and Joint Session II

9:30-12:10 [160]

Chairs: Shinya Suzu and Keiko Sakai

[40] 19 Tao Dong

Extensive HLA-driven viral diversity following a

(University of Oxford, UK)

single-source HIV-1 outbreak in rural China

Plenary Talk

[30] 20 Hirotomo Nakata

CCR5 receptors form functional clusters upon their

(National Cancer Institute, USA) interactions with HIV gp120/gp41 trimers

10:40-11:10

[30] 21 Shogo Misumi (Kumamoto Univ.)

UNCOATING OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REQUIRES PROLYL ISOMERASE PIN1

11:10-11:40 11:40-12:10

[30] 22 Kosuke Miyauchi

The productive endocytosis of HIV-1

(National Institute of

Infectious Diseases)

[20] 23 Joseph Ziegelbauer

Human target genes of viral microRNAs expressed by

(National Cancer Institute, USA) Kaposi's sarcoma-associated herpesvirus

12:10-14:10

[120]

Lunch / Panel Discussion II

Parallel Session V: Immune Responses II

14:10-15:30 [80]

Chairs: Masao Hashimoto and Hayato Murakoshi

14:10-14:30

[20] 24 Hiroyuki Yamamoto

Non-sterile SIV control by neutralizing antibodies: window

(University of Tokyo)

period for a B-to-T.

14:30-14:50

[20] 25 Teppei Toda (Kumamoto Univ.)

Inhibition of HIV-1 infection by novel anti-CD4 monoclonal antibody

14:50-15:10

[20] 26 Philip Mwimanzi (Kumamoto Univ.)

The effects of CTL-escape conferring mutations on Nef's pathogenic functions in primary macrophages.

15:10-15:30

[20] 27 Kazutaka Honda (Kumamoto Univ.)

15:30-16:00

[30]

Parallel Session VI: Immune Responses III

Chairs: Masumichi

16:00-16:30

[30] 28 Maximillian Rosario

(University of Oxford, UK)

16:30-16:50

[20] 29 Nan Zheng (Kumamoto Univ.)

Saito

Selection of escape mutant by HLA-C-restricted HIV-1 Pol-specific cytotoxic T lymphocytes having a strong ability to suppress HIV-1 replication
Coffee Break
16:00-17:10 [70] and Chihiro Motozono
Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques Roles of CD4+ T Cells in the Control of HIV Infection: The Victim Strikes Back

16:50-17:10 17.10-17:20

[20] 30 Keiko Sakai (Kumamoto Univ.)
[10] Closing Remark

Correlation between nadir CD4 counts and skewed distributions of CD4+ T-cell subsets in patients chronically infected with HIV-1

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2nd floor, CAIDS 14:10 - 17:20

Parallel Session VII: Therapy and Epidemiology

14:10-15:30 [80]

Chairs: Hiroyuki Gatanaga and Kazuhiko Ide

14:10-14:30

[20] 31 Takeshi Nishijima

The impact of Tenofovir disoproxil fumarate on renal

(International Medical

function among Japanese patients with HIV-1 infection

Center of Japan)

14:30-14:50

[20] 32 Tamayo Watanabe

Trends of AIDS indicative diseases, malignancies, and cause

(International Medical

of death in HIV-1-infected patients in Japan.

Center of Japan)

14:50-15:10

[20] 33 Jagdagsuren Davaalkham

Current status of HIV infection in Mongolia: Expanding

(International Medical

trend of HIV-1 subtype B among MSM

Center of Japan)

15:10-15:30

[20] 34 Shiro Ibe

Identification of the first circulating recombinant form of

(Nagoya Medical Center)

HIV-2, CRF01_AB

15:30-16:00 16:00-16:30 16:30-16:50

[30]

Coffee Break

Parallel Session VIII: Pathogenesis II

16:00-17:10 [70]

Chairs: Takeo Kuwata and Masateru Hiyoshi

[30] 35 Ken Kono

Viral and host determinants for the restriction of human

(Osaka Univ.)

immunodeficiency virus type 2/simian immunodeficiency

[20] 36 Taisuke Izumi

virus SIVmac by rhesus monkey TRIM5α A novel HIV-1 Vif function is mediated by interaction with

(Kyoto Univ.)

oncoprotein p53

16:50-17:10 17.10-17:20

[20] 37 Terumasa Ikeda (Kumamoto University)
[10] Closing Remark

Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons

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